Change Point Detection in Cognitive Decline using Longitudinal Data with Floor
and Ceiling Effects 
   Lead Investigator:    Ming Ji
   Institution      :    University of South Florida College of Nursing
   E-Mail           :    mji@health.usf.edu
   Proposal ID      :    621



   Proposal Description:
   1) The goals of the proposed research are to develop statistical methods and      software for further validating the hypothesis of sudden cognitive decline and    the onset of Alzheimer's Disease.                                                                                                                                   2)The specific objectives are:                                                    (a) develop a Bayesian approach for detecting change points in longitudinal       MMSE scores with floor/ceiling effects and possibly nonignorable missing data.                                                                                      (b) develop WINBUG/R codes for implementation of such statistical methods for     Alzheimer's Disease researchers.